Oncological outcomes of cryosurgery as primary treatment in T3 prostate cancer: experience of a single centre
作者： Zhi Guo , Tongguo Si , Xueling Yang , Yan Xu
DOI: 10.1111/BJU.12914
关键词:
摘要: Objective To assess the oncological outcomes and determine prognostic factors for overall survival (OS), cancer-specific (CSS), biochemical progression-free (BPFS) after cryosurgery clinical stage T3 prostate cancer. Patients Methods Between 2002 2007, 75 patients with cancer received as primary treatment in our institution. No adjuvant was provided until failure. After failure, hormone therapy administered. Kaplan–Meier analysis used to calculate OS, CSS, BPFS. Cox regression identify predictive of survival. Results Clinical T3a (cT3a) detected 60% (45/75) cT3b 40% (30/75). The 5-year BPFS rates were 85.3%, 92.0%, 48%, respectively. There a significant difference when comparing pT3a pT3b group OS (88.9% vs 80%, P = 0.02) (55.6% 36.7%, 0.01), but there no CSS (93.3% 90%, 0.63). Stage, Gleason score, nadir prostate-specific antigen (PSA) associated BPFS, while score PSA most predictors CSS. Conclusions Cryosurgery can offer good cT3 cancer, between T3b CSS. survival. Further trials are warranted evaluating role cancer.
sci-hub.se 参考文章(30)
John F. Ward, Christopher J. DiBlasio, Christopher Williams, Robert Given, J. Stephen Jones, Cryoablation for locally advanced clinical stage T3 prostate cancer: a report from the Cryo-On-Line Database (COLD) Registry. BJUI. ,vol. 113, pp. 714- 718 ,(2014) , 10.1111/BJU.12476
M. Manoharan, V.G. Bird, S.S. Kim, F. Civantos, M.S. Soloway, Outcome after radical prostatectomy with a pretreatment prostate biopsy Gleason score of ≥8 BJUI. ,vol. 92, pp. 539- 544 ,(2003) , 10.1046/J.1464-410X.2003.04419.X
Michael J. Zelefsky, Yoshiya Yamada, Marisa A. Kollmeier, Alison M. Shippy, Michelle A. Nedelka, Long-Term Outcome Following Three-Dimensional Conformal/Intensity-Modulated External-Beam Radiotherapy for Clinical Stage T3 Prostate Cancer European Urology. ,vol. 53, pp. 1172- 1179 ,(2008) , 10.1016/J.EURURO.2007.12.030
Michael L. Eisenberg, Benjamin J. Davies, Matthew R. Cooperberg, Janet E. Cowan, Peter R. Carroll, Prognostic Implications of an Undetectable Ultrasensitive Prostate-Specific Antigen Level after Radical Prostatectomy European Urology. ,vol. 57, pp. 622- 630 ,(2010) , 10.1016/J.EURURO.2009.03.077
Bryan J. Donnelly, John C. Saliken, Penelope M. A. Brasher, Scott D. Ernst, John C. Rewcastle, Harold Lau, John Robinson, Kiril Trpkov, A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer Cancer. ,vol. 116, pp. 323- 330 ,(2010) , 10.1002/CNCR.24779
Brett S. Carver, Fernando J. Bianco, Peter T. Scardino, James A. Eastham, Long-Term Outcome Following Radical Prostatectomy in Men With Clinical Stage T3 Prostate Cancer The Journal of Urology. ,vol. 176, pp. 564- 568 ,(2006) , 10.1016/J.JURO.2006.03.093
Gregory P. Swanson, Bryan Goldman, Catherine M. Tangen, Joseph Chin, Edward Messing, Edith Canby-Hagino, Jeffrey D. Forman, Ian M. Thompson, E. David Crawford, The Prognostic Impact of Seminal Vesicle Involvement Found at Prostatectomy and the Effects of Adjuvant Radiation: Data From Southwest Oncology Group 8794 Journal of Urology. ,vol. 180, pp. 2453- 2458 ,(2008) , 10.1016/J.JURO.2008.08.037
Chao-Yu Hsu, Steven Joniau, Raymond Oyen, Tania Roskams, Hein Van Poppel, None, Outcome of Surgery for Clinical Unilateral T3a Prostate Cancer: A Single-Institution Experience European Urology. ,vol. 51, pp. 121- 129 ,(2007) , 10.1016/J.EURURO.2006.05.024
John F. Ward, Jeffrey M. Slezak, Michael L. Blute, Erik J. Bergstralh, Horst Zincke, Radical prostatectomy for clinically advanced (cT3) prostate cancer since the advent of prostate‐specific antigen testing: 15‐year outcome BJUI. ,vol. 95, pp. 751- 756 ,(2005) , 10.1111/J.1464-410X.2005.05394.X
Stephen J. Freedland, Alan W. Partin, Elizabeth B. Humphreys, Leslie A. Mangold, Patrick C. Walsh, Radical prostatectomy for clinical stage T3a disease. Cancer. ,vol. 109, pp. 1273- 1278 ,(2007) , 10.1002/CNCR.22544