Characterization of intrahepatic cholangiocarcinoma of the intraductal growth-type and its precursor lesions
作者： Ta-Sen Yeh , Jeng-Hwei Tseng , Tse-Ching Chen , Nai-Jen Liu , Cheng-Tang Chiu
DOI: 10.1002/HEP.20837
关键词:
摘要: A cohort of patients with intraductal growth-type intrahepatic cholangiocarcinoma (IG-ICC) and its precursor lesions, collectively termed papillary neoplasm the liver (IPNL), was characterized respect to demographics, clinical manifestations, perioperative management, long-term survival, molecular features associated carcinogenesis. total 122 IPNL types 1 through 4, 108 non-IG-ICC 210 hepatolithiasis alone were studied. Expression CDX2, TFF1, MUC1, MUC2, MUC5AC, EGFR, p53 determined by using immunohistochemistry. Females predominated in those IPNL. The mean age 6 8 years younger than that association 2, 3 100%, 79%, 64%, respectively. Mucobilia, anemia, elevated serum carcinoembryonic antigen levels helpful distinguishing IG-ICC lesions. survival type 3, 55.5 months, 36.9 15.8 incidence expression CDX2 TFF1 maximal 3. cellular distribution MUC2 similar. MUC5AC strongly expressed all IPNL; EGFR rarely In conclusion, appears be a precipitating factor development Signs mucobilia specific for diagnosis are differentiating non-IG-ICC. Significant differences various lesions studied warrants more aggressive surgical strategy their management.
sci-hub.se 参考文章(34)
Tse‐Ching Chen, Yasuni Nakanuma, Yoh Zen, Miin‐Fu Chen, Yi‐Yin Jan, Ta‐Sen Yeh, Cheng Tang Chiu, Tseng‐Tong Kuo, Jun‐ichi Kamiya, Koji Oda, Michinari Hamaguchi, Yoshiyuki Ohno, Ling‐Ling Hsieh, Yuji Nimura, Intraductal papillary neoplasia of the liver associated with hepatolithiasis Hepatology. ,vol. 34, pp. 651- 658 ,(2001) , 10.1053/JHEP.2001.28199
Miin-Fu Chen, Yi-Yin Jan, Tsann-Long Hwang, Long-Bin Jeng, Ta-Sen Yeh, Impact of Concomitant Hepatolithiasis on Patients with Peripheral Cholangiocarcinoma Digestive Diseases and Sciences. ,vol. 45, pp. 312- 316 ,(2000) , 10.1023/A:1005460509677
Kanenori Endo, Byung-IL Yoon, Chawalit Pairojkul, Anthony J. Demetris, Alphonse E. Sirica, ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. Hepatology. ,vol. 36, pp. 439- 450 ,(2002) , 10.1053/JHEP.2002.34435
Akashi Eda, Hiroyuki Osawa, Kiichi Satoh, Ichiro Yanaka, Ken Kihira, Yumiko Ishino, Hiroyuki Mutoh, Kentaro Sugano, Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa. Journal of Gastroenterology. ,vol. 38, pp. 14- 22 ,(2003) , 10.1007/S005350300001
O. Lefebvre, M.-P. Chenard, R. Masson, J. Linares, A. Dierich, M. LeMeur, C. Wendling, C. Tomasetto, P. Chambon, M.-C. Rio, Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein Science. ,vol. 274, pp. 259- 262 ,(1996) , 10.1126/SCIENCE.274.5285.259
Ping Ren, Debra G. Silberg, Alphonse E. Sirica, Expression of an intestine-specific transcription factor (CDX1) in intestinal metaplasia and in subsequently developed intestinal type of cholangiocarcinoma in rat liver. American Journal of Pathology. ,vol. 156, pp. 621- 627 ,(2000) , 10.1016/S0002-9440(10)64766-9
J. Downward, Y. Yarden, E. Mayes, G. Scrace, N. Totty, P. Stockwell, A. Ullrich, J. Schlessinger, M. D. Waterfield, Close similarity of epidermal growth factor receptor and v- erb-B oncogene protein sequences Nature. ,vol. 307, pp. 521- 527 ,(1984) , 10.1038/307521A0
Tomonori Shimonishi, Yoh Zen, Tse-Ching Chen, Miin-Fu Chen, Yi-Yin Jan, Ta-Sen Yeh, Yuji Nimura, Yasuni Nakanuma, Increasing expression of gastrointestinal phenotypes and p53 along with histologic progression of intraductal papillary neoplasia of the liver Human Pathology. ,vol. 33, pp. 503- 511 ,(2002) , 10.1053/HUPA.2002.124030
Anna Velcich, WanCai Yang, Joerg Heyer, Alessandra Fragale, Courtney Nicholas, Stephanie Viani, Raju Kucherlapati, Martin Lipkin, Kan Yang, Leonard Augenlicht, Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. ,vol. 295, pp. 1726- 1729 ,(2002) , 10.1126/SCIENCE.1069094
Kyung-Suk Suh, Hye Rin Roh, Young Taeg Koh, Kuhn Uk Lee, Yong-Hyun Park, Sun-Whe Kim, Clinicopathologic features of the intraductal growth type of peripheral cholangiocarcinoma. Hepatology. ,vol. 31, pp. 12- 17 ,(2000) , 10.1002/HEP.510310104