Calcium-sensitive modulation of the actomyosin ATPase by fodrin.
作者： P D Wagner
DOI: 10.1016/S0021-9258(20)82141-3
关键词:
摘要: Fodrin, a spectrin-like protein isolated from brain, is long flexible molecule which binds calmodulin and cross-links F-actin. The effects of fodrin on the actin-activated ATPase myosin have been examined. When added after ATP, inhibited actomyosin ATPase. Two to three times as much was required for inhibition in presence Ca2+ its absence. Complete absence occurred at about one 200 actins. Inhibition does not appear result cross-linking F-actin, and, thereby, preventing filaments reaching actin filaments; but may promote by trapping within cross-linked before stimulated almost 3-fold less than 50% Ca2+. Stimulation thought After several minutes stimulations were greatly reduced, ATPases substantially inhibited. Whether or subfragment 1. This also slightly sensitive.
sci-hub.st 参考文章(31)
Paul D. Wagner, Alan G. Weeds, Studies on the role of myosin alkali light chains. Recombination and hybridization of light chains and heavy chains in subfragment-1 preparations. Journal of Molecular Biology. ,vol. 109, pp. 455- 470 ,(1977) , 10.1016/S0022-2836(77)80023-5
Allan G. Gornall, Charles J. Bardawill, Maxima M. David, Determination of serum proteins by means of the biuret reaction. Journal of Biological Chemistry. ,vol. 177, pp. 751- 766 ,(1949) , 10.1016/S0021-9258(18)57021-6
D Wallach, P J Davies, M C Willingham, M Yamaguchi, R M Robson, I Pastan, Filamin-actin interaction. Dissociation of binding from gelation by Ca2+-activated proteolysis. Journal of Biological Chemistry. ,vol. 253, pp. 4036- 4042 ,(1978) , 10.1016/S0021-9258(17)34795-6
K Weber, J R Glenney, P Glenney, F-actin-binding and cross-linking properties of porcine brain fodrin, a spectrin-related molecule. Journal of Biological Chemistry. ,vol. 257, pp. 9781- 9787 ,(1982) , 10.1016/S0021-9258(18)34140-1
P Cheung, E Reisler, The actomyosin ATPase of synthetic myosin minifilaments, filaments, and heavy meromyosin. Journal of Biological Chemistry. ,vol. 258, pp. 5040- 5044 ,(1983) , 10.1016/S0021-9258(18)32534-1
John R. Glenney, Phyllis Glenney, Klaus Weber, Mapping the fodrin molecule with monoclonal antibodies: A general approach for rod-like multidomain proteins Journal of Molecular Biology. ,vol. 167, pp. 275- 293 ,(1983) , 10.1016/S0022-2836(83)80336-2
Tadashi SHIMO-OKA, Yoshio WATANABE, Stimulation of Actomyosin Mg2+-ATPase Activity by a Brain Microtubule-Associated Protein Fraction--High-Molecular Weight Actin-Binding Protein Is the Stimulating Factor Journal of Biochemistry. ,vol. 90, pp. 1297- 1307 ,(1981) , 10.1093/OXFORDJOURNALS.JBCHEM.A133595
Elizabeth A. Repasky, Bruce L. Granger, Elias Lazarides, Widespread occurrence of avian spectrin in nonerythroid cells Cell. ,vol. 29, pp. 821- 833 ,(1982) , 10.1016/0092-8674(82)90444-5
Sally A. Mulhern, Evan Eisenberg, Interaction of spin-labeled and N-(iodacetylaminoethyl)-5-naphthylamine-1-sulfonic acid SH1-blocked heavy meromyosin and myosin with actin and adenosine triphosphate. Biochemistry. ,vol. 17, pp. 4419- 4425 ,(1978) , 10.1021/BI00614A010
R K Carlin, D C Bartelt, P Siekevitz, Identification of fodrin as a major calmodulin-binding protein in postsynaptic density preparations. Journal of Cell Biology. ,vol. 96, pp. 443- 448 ,(1983) , 10.1083/JCB.96.2.443