Translation of In Vitro Metabolic Data to Predict In Vivo Drug–Drug Interactions: IVIVE and Modeling and Simulations

摘要: For many years, researchers have been able to study xenobiotic metabolism using several in vitro systems. However, quantitative translation of the information, which requires appropriate understanding link between these systems and human body, is still its infancy. Recent progress biology, advent powerful computers capable handling numerous complicated non-linear models realization that there virtually no end number various studies would be required cover all possible permutations clinical scenarios can occur real life contributed increased prominence vitro–in vivo extrapolation (IVIVE) virtual modeling simulation drug discovery development. This chapter provides an overview translational aspects describes prerequisite data, tools applied for prediction metabolic drug–drug interactions (M-DDI).