Noxious Stimulus-Induced Plasticity in Spinal Cord Dorsal Horn: Evidence and Insights on Mechanisms Obtained Using the Formalin Test
作者： Terence J. Coderre
DOI: 10.1007/978-1-4615-1437-4_7
关键词:
摘要: After tissue or nerve injury, animals develop an increased sensitivity to noxious and non-noxious cutaneous stimuli, paralleling the development of hyperalgesia allodynia in humans. While these changes depend partly on sensitization peripheral tissues, there is also evidence that depends within central nervous system (CNS). Central after neural injury has been defined as a change excitability CNS neurons which triggered by outlasts nociceptive afferent inputs (Woolf Chong, 1993). There indicating persistent responses chemical stimulation with formalin spinal cord neurons, occurs early period injury. Indeed, test used now for 10 years animal model stimulus-induced plasticity. In this paper, I will debate supporting view reflects neurons. Additionally, discuss some potential mediators lead injury-induced plasticity cord.
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