Src homology 2 domain–containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ-MiR-155 transgenic mice

摘要: We showed that Emicro-MiR-155 transgenic mice develop acute lymphoblastic leukemia/high-grade lymphoma. Most of these leukemias start at approximately 9 months irrespective the mouse strain. They are preceded by a polyclonal pre-B-cell proliferation, have variable clinical presentation, transplantable, and oligo/monoclonal expansion. In this study, we show in B-cell precursors highest MiR-155 transgene expression origin leukemias. determine Src homology 2 domain-containing inositol-5-phosphatase (SHIP) CCAAT enhancer-binding protein beta (C/EBPbeta), important regulators interleukin-6 signaling pathway, direct targets become gradually more down-regulated leukemic than preleukemic mice. hypothesize miR-155, down-modulating Ship C/EBPbeta, initiates chain events leads to accumulation large pre-B cells