Recognizing misfolded proteins in the endoplasmic reticulum.

作者: Andreas Matouschek

DOI: 10.1038/74012

关键词:

摘要: The mechanism by which cells recognize misfolded proteins in the endoplasmic reticulum has been defined at cell biological level. enzyme UDP-glucose:glycoprotein glucosyltransferase identifies and specifically glucosylates domains within a multi-domain protein.

参考文章(31)
A. Vassilakos, M. F. Cohen-Doyle, P. A. Peterson, M. R. Jackson, D. B. Williams, The molecular chaperone calnexin facilitates folding and assembly of class I histocompatibility molecules. The EMBO Journal. ,vol. 15, pp. 1495- 1506 ,(1996) , 10.1002/J.1460-2075.1996.TB00493.X
Ari Helenius, Christiane Ritter, Recognition of local glycoprotein misfolding by the ER folding sensor UDP-glucose:glycoprotein glucosyltransferase Nature Structural & Molecular Biology. ,vol. 7, pp. 278- 280 ,(2000) , 10.1038/74035
Kerstin Braig, Zbyszek Otwinowski, Rashmi Hegde, David C. Boisvert, Andrzej Joachimiak, Arthur L. Horwich, Paul B. Sigler, The crystal structure of the bacterial chaperonin GroEL at 2.8 A. Nature. ,vol. 371, pp. 578- 586 ,(1994) , 10.1038/371578A0
Bernd Bukau, Arthur L Horwich, The Hsp70 and Hsp60 Chaperone Machines Cell. ,vol. 92, pp. 351- 366 ,(1998) , 10.1016/S0092-8674(00)80928-9
Laura S. Itzhaki, Daniel E. Otzen, Alan R. Fersht, Nature and Consequences of GroEL-Protein Interactions Biochemistry. ,vol. 34, pp. 14581- 14587 ,(1995) , 10.1021/BI00044A037
Hong Wang, Alexander V. Kurochkin, Yuxi Pang, Weidong Hu, Gregory C. Flynn, Erik R. P. Zuiderweg, NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction. Biochemistry. ,vol. 37, pp. 7929- 7940 ,(1998) , 10.1021/BI9800855
J Lowe, D Stock, B Jap, P Zwickl, W Baumeister, R Huber, Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution. Science. ,vol. 268, pp. 533- 539 ,(1995) , 10.1126/SCIENCE.7725097
Sylvie Blond-Elguindi, Steven E Cwirla, William J Dower, Robert J Lipshutz, Stephen R Sprang, Joseph F Sambrook, Mary-Jane H Gething, Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP. Cell. ,vol. 75, pp. 717- 728 ,(1993) , 10.1016/0092-8674(93)90492-9