TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration
作者： N Nielsen , O Lindemann , A Schwab
DOI: 10.1111/BPH.12721
关键词:
摘要: Cancer cells are strongly influenced by host within the tumour stroma and vice versa. This leads to development of a microenvironment with distinct physical chemical properties that permissive for progression. The ability migrate plays central role in this mutual interaction. Migration cancer is considered as prerequisite metastasis migration stromal required reaching site. Increasing evidence suggests transient receptor potential (TRP) channels STIM/ORAI proteins affect key calcium-dependent mechanisms implicated both cell migration. These include, among others, cytoskeletal remodelling, growth factor/cytokine signalling production, adaptation microenvironmental such hypoxia oxidative stress. In review, we will summarize current knowledge regarding TRP We focus on how channel or STIM/ORAI-mediated Ca2+ directly indirectly influences affecting above listed mechanisms. Linked Articles This article part themed section Cytoskeleton, Extracellular Matrix, Cell Migration, Wound Healing Related Topics. To view other articles visit http://dx.doi.org/10.1111/bph.2014.171.issue-24
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