Pathological and clinical significance of increased intraepithelial lymphocytes (IELs) in small bowel mucosa

摘要: Intestinal intraepithelial lymphocytes (IELs) belong to a unique T-cell population interspersed between epithelial cells of both the small and large intestine. It is becoming increasingly recognised that an increased number IELs with normal villous architecture within wide spectrum histological abnormalities observed in coeliac disease. An earliest pathological change following gluten challenge high IEL count may be only sign sensitivity. Therefore, finding raised sufficient clinical importance reported routine bowel biopsies. However, it evident not all intestinal biopsy specimens showing are explained by Increased mucosa have also been associated autoimmune disorders, tropical sprue, food protein intolerance, Helicobacter pylori-associated gastritis, peptic duodenitis, parasitic viral infections, as well development lymphoma. Histological examination specimen remains diagnostic gold standard for There will ever increasing demand confirmation sensitivity patients whom classic microscopic appearance flattened villi fully developed. The more widespread recognition histopathologists pattern injury manifested numbers certainly help early diagnosis disease, lessen confusion influence modern practice gastrointestinal tract medicine. This review discusses some recent developments pathology pertaining mucosal