Heterogeneity of alpha-2 adrenergic receptors.

摘要: Alpha adrenergic receptors are subdivided into alpha-1 and alpha-2 subtypes on the basis of their pharmacologic properties. An evaluation data from radioligand binding functional experiments indicates that classified as not a homogeneous group. The best example this heterogeneity is differences in properties rodent non-rodent mammalian species. Prazosin generally has high affinity for receptors, but low while oxymetazoline more potent at receptors. A definition receptor proposed with prazosin having lower (200-300 nM) alpha-2A higher (5-10 alpha-2B Using definition, human platelet appears to have only subtype, all neonatal rat lung subtype. brain roughly equal amounts -2B submandibular gland, about 85% alpha-2A. ability pharmacologically define putative should promote development additional subtype selective drugs which will increase our understanding pharmacology may provide new therapeutic approaches.