Targeting the bacterial SOS response for new antimicrobial agents: drug targets, molecular mechanisms and inhibitors.
关键词:
摘要: Antimicrobial resistance is a pressing threat to global health, with multidrug-resistant pathogens becoming increasingly prevalent. The bacterial SOS pathway functions in response DNA damage that occurs during infection, initiating several pro-survival and mechanisms, such as repair hypermutation. This makes components potential targets may combat drug-resistant decrease emergence. review discusses the mechanism of pathway; structure function AddAB, RecBCD, RecA LexA; efforts develop selective small-molecule inhibitors these proteins. These serve valuable tools for target validation provide foundations desperately needed novel antibacterial therapeutics.
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