Photophysics and photochemistry of hematoporphyrin, hematoporphyrin derivative and uroporphyrin I.
作者： L. I. Grossweiner , A. Blum , G. C. Goyal
DOI: 10.1007/978-1-4613-2165-1_21
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摘要: The putative action mechanism in photodynamic therapy (PDT) involves serum transport of HPD to tumor tissue, localization and retention the active constituent, generation singlet molecular oxygen (Δ) by visible light attack t on cellular targets. Early workers postulated that tissue membranes are key targets PDT (Dougherty et al., 1978), which is consistent with evidence photosensitization red blood cell protoporphyrin mediated Δ (Lamola 1973). Subsequent studies model hematoporphyrin (HP) this hypothesis. However, specific have not been identified involvement non- membrane has ruled out. a porphyrin mixture leading complicated dependence photophysical photochemical properties medium. constituent adequately characterized, although there it covalent dimer or oligomer units (Berenbaum ai., 1982; Dougherty 1984; Swincer 1985). al. (1984) refer material as dihematoporphyrin ether (DHE), will be used for convenience paper, structure implied terminology proven. present results were obtained an enriched prepared poiyacryiamide gel filtration referred HpD-A (Grossweiner Goyal, 1983).
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