A cell cycle hypothesis of cooperative oncogenesis (Review).

摘要: The development of cancer is a multistep process. To understand oncogenesis and adapt appropriate treatments it important to have better definition number factors, including the order oncogenic steps, identity targeted cells deregulated cellular components, genes pathways altered at each step. We propose here hypothesis based on targeting cell cycle in two major steps. Oncogenic hits may occur sequences: one scenario first hit alters regulation G1 phase leading proliferative, premalignant syndrome; completed when second relieves checkpoints late phases cycle. Alternatively, genetic alteration first; this leads disease with signs senescence. In scenario, targets phase. sequences, cooperation different relieving checkpoints. Stem progenitor various tissues be variably sensitive these hits.