Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
作者： Hui-Kuan Lin , Guocan Wang , Zhenbang Chen , Julie Teruya-Feldstein , Yan Liu
DOI: 10.1038/NCB1849
关键词:
摘要: Skp2 is a known component of the SCF ubiquitin ligase that ubiquitylates cell-cycle regulator p27. Akt kinase directly phosphorylates and regulates complex assembly activity, cytoplasmic localization Skp2-dependent regulation cell proliferation migration.
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