Protein damage and degradation by oxygen radicals. II. Modification of amino acids.
作者： K J Davies , M E Delsignore , S W Lin
DOI: 10.1016/S0021-9258(18)48019-2
关键词:
摘要: Exposure of proteins to the hydroxyl radical (. OH) or to the combination of. OH plus the superoxide anion radical (. OH+ O2-) causes gross structural modification. Such modified proteins can undergo spontaneous fragmentation or can exhibit substantial increases in proteolytic susceptibility. In the present study, with the representative protein bovine serum albumin (BSA), we report that alterations to primary structure underlie such gross structural modifications. All amino acids in BSA were susceptible to modification by both. OH and. OH+ …
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