The role of afferent activity in the maintenance of primate neocorticalfunction

摘要: The major neuronal populations of the primate cerebral cortex can be classified immunocytochemically according to their transmitters and in terms differential expression certain other molecules such as neuropeptides, calcium-binding proteins protein kinases. We have been able chart time course developmental these show that gene for many them is regulated adult infant animals by afferent activity entering cortex. In visual monkeys, levels detectable gamma aminobutyric acid (GABA), its synthesizing enzyme glutamic decarboxylase (GAD) tachykinins are greatly reduced deprived ocular dominance columns within 24 h blocking impulse optic nerve intraocular injection tetrodotoxin (TTX). Conversely, calcium-calmodulin-dependent kinase (CAMII kinase) increased eye columns. These effects quickly reversible on restoration binocular vision, experiments involving situ hybridization S1 nuclease protection assays changes associated with parallel mRNA preprotachykinin CAM II kinase, but not GAD, which appears post-transcriptional mechanisms. Experiments somatic sensory suggest comparable activity-dependent there also. It proposed this type underlie establishment cortical maps during development mutability adulthood.