Calcium is an intracellular mediator of the climbing fiber in induction of cerebellar long-term depression.

摘要: In cerebellar Purkinje cells, conjunctive stimulation of parallel fibers and the climbing fiber causes long-term depression fiber-Purkinje cell transmission. It has been postulated that calcium is an intracellular mediator to induce this synaptic modification. To directly test hypothesis, a calcium-chelating agent, EGTA, was intracellularly injected into cells. these failed depression. Instead, it caused potentiation similar observed after repetitive alone.