Solid Phospholipid Dispersions for Oral Delivery of Poorly Soluble Drugs: Investigation Into Celecoxib Incorporation and Solubility-In Vitro Permeability Enhancement

摘要: Celecoxib (CXB) is a Biopharmaceutical Classification System class II drug in which its oral bioavailability limited by poor aqueous solubility. Although range of formulations aiming to increase the solubility CXB have been developed, it not completely understood, whether (1) an leads subsequent permeability across intestinal barrier and (2) presence bile salts affects behavior formulations. By formulating solid phospholipid (PL) dispersions with various PL-to-drug ratios using freeze drying, present study illustrated that enhancement was proportionally translated into enhanced permeability; both parameters were highly dependent on as well dispersion media (i.e., 3-mM sodium taurocholate). This highlights importance evaluating both, permeability, use biorelevant medium for testing candidate-enabling performance liposomal Mechanisms at molecular level may explain effect PL are also discussed.