Distinct NMDA Receptor Subpopulations Contribute to Long-Term Potentiation and Long- Term Depression Induction
作者： Sabina Hrabetova , Peter Serrano , Nancy Blace , Heong W. Tse , Donald A. Skifter
DOI: 10.1523/JNEUROSCI.20-12-J0002.2000
关键词:
摘要: Long-term potentiation (LTP) and long-term depression (LTD) are persistent modifications of synaptic strength that have been implicated in learning, memory, neuronal development. Despite their opposing effects, both forms plasticity can be triggered by the activation NMDA receptors. One mechanism proposed for this bidirectional response is specific patterns afferent stimulation producing LTP LTD activate to different degrees a uniform receptor population. A second possibility these separate subpopulations composed (NR) subunits. To test hypothesis we examined inhibition series competitive antagonists varied affinities NR2A/B NR2C/D The potency compared with widely among agents. Antagonists higher affinity subunits relative NRC/D showed more potent than LTD. D-3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid, which binds very high NR2C/D, an approximately 1000-fold These results show distinct receptors characterized NR2 contribute induction mechanisms depression.
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