Cyclotriphosphate: A Brief History, Recent Developments, and Perspectives in Synthesis

摘要: There has been a recent upsurge in the study and application of approaches utilizing cyclotriphosphate 1 (cyclo-TP, also known as trimetaphosphate, TMP) and/or proceeding through its analogues synthetic chemistry to access modified oligo- polyphosphates. This is especially useful area chemical nucleotide synthesis, but by no means restricted it. Enabled new high yielding easy-to-implement methodologies, these promise open up an research that previously underappreciated. Additionally, refinements concepts prebiotic phosphorylation have disclosed ultimately rely on cyclo-TP 1 precursor, placing it potentially central compound emergence life. Given importance such for our understanding combination with need readily polyphosphates structural biological studies, this paper will discuss selected developments field cyclo-TP chemistry, briefly touch ultraphosphate highlight areas which further can be expected.