Gamma-tocopherol ameliorates hyperglycemia-induced hepatic inflammation associated with NLRP3 inflammasome in alloxan-induced diabetic mice

摘要: Background/objectives Hyperglycemia-induced hepatic damage has been recognized as one of the major cause complications in diabetes. Hepatic are associated with inflammation and oxidative stress In this study, we investigated hypothesis that gamma-tocopherol (GT) supplementation ameliorates NLRP3 inflammasome Materials/methods Diabetes was induced by intraperitoneal injection alloxan (150 mg/kg. BW) ICR mice. All mice were fed a control diet (AIN-76A). After diabetes (fasting glucose level ≥ 250 mg/dL), treated tocopherol-stripped corn oil or GT-supplemented (35 mg/kg) oil, respectively, gavage for 2 weeks. Results GT reduced fasting blood levels diabetic relative to non-treated Moreover, ameliorated hyperglycemia-induced regulation NOD-like receptor protein 3 (NLRP3)-inflammasome represented NLRP3, apoptosis-associated speck-like containing caspase-recruitment domain, caspase-1, nuclear factor-κB pathway well demonstrated factor erythroid 2-related 2, NAD(P)H dehydrogenase quinone 1, catalase glutathione-dependent peroxidase Conclusion The findings suggested attenuating alloxan-induced Taken together, could be beneficial nutrient can ameliorate inflammatory responses damage.