摘要: Long-term potentiation (LTP) is a strengthening of synaptic transmission that was first discovered in the hippocampus (Bliss and Lomo, 1973). If one stimulates afferents to at high rate (100 Hz for 3 sec), excitatory postsynaptic potentials hippocampal pyramidal cells are subsequently found be larger than normal, rise more quickly. The effect lasts several hours, can last as long preparation does.
springer.com
sci-hub.st 参考文章(56)
K. Fox, H. Sato, N. Daw, The effect of varying stimulus intensity on NMDA-receptor activity in cat visual cortex. Journal of Neurophysiology. ,vol. 64, pp. 1413- 1428 ,(1990) , 10.1152/JN.1990.64.5.1413
G L Collingridge, C E Herron, R A Lester, Frequency-dependent N-methyl-D-aspartate receptor-mediated synaptic transmission in rat hippocampus. The Journal of Physiology. ,vol. 399, pp. 301- 312 ,(1988) , 10.1113/JPHYSIOL.1988.SP017081
DM Bannerman, PF Chapman, PA Kelly, SP Butcher, RG Morris, Inhibition of nitric oxide synthase does not impair spatial learning The Journal of Neuroscience. ,vol. 14, pp. 7404- 7414 ,(1994) , 10.1523/JNEUROSCI.14-12-07404.1994
PK Stanton, JM Sarvey, Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis The Journal of Neuroscience. ,vol. 4, pp. 3080- 3088 ,(1984) , 10.1523/JNEUROSCI.04-12-03080.1984
Y. Komatsu, K. Fujii, J. Maeda, H. Sakaguchi, K. Toyama, Long-term potentiation of synaptic transmission in kitten visual cortex Journal of Neurophysiology. ,vol. 59, pp. 124- 141 ,(1988) , 10.1152/JN.1988.59.1.124
R. Zalutsky, R. Nicoll, Comparison of two forms of long-term potentiation in single hippocampal neurons Science. ,vol. 248, pp. 1619- 1624 ,(1990) , 10.1126/SCIENCE.2114039
S Nakanishi, Molecular diversity of glutamate receptors and implications for brain function. Science. ,vol. 258, pp. 597- 603 ,(1992) , 10.1126/SCIENCE.1329206
R. Mulkey, C. Herron, R. Malenka, An essential role for protein phosphatases in hippocampal long-term depression Science. ,vol. 261, pp. 1051- 1055 ,(1993) , 10.1126/SCIENCE.8394601
Kevin Fox, Nigel Daw, A model for the action of NMDA conductances in the visual cortex Neural Computation. ,vol. 4, pp. 59- 83 ,(1992) , 10.1162/NECO.1992.4.1.59
Georg A. Böhme, Christelle Bon, Jean-Marie Stutzmann, Adam Doble, Jean-Charles Blanchard, Possible involvement of nitric oxide in long-term potentiation. European Journal of Pharmacology. ,vol. 199, pp. 379- 381 ,(1991) , 10.1016/0014-2999(91)90505-K