Role of the prenatal environment in the development of obesity.

摘要: Establishing that prenatal life is a critical or sensitive period for the development of obesity may focus basic research and clinical prevention efforts on this period. This review summarizes evidence intrauterine environment influences risk later considers mechanisms by which occur. The association between birth weight adult suggests there are enduring effects risk. We examine whether maternal factors diabetes, obesity, pregnancy gain alter thereby increase in offspring. Of these factors, strongest role diabetes. No single mechanism explains how could change to However, all potential involve an altered transfer metabolic substrates mother fetus, influence developing structure function organs involved energy metabolism.