Zebrafish (Danio rerio) as a model for the study of aging and exercise: physical ability and trainability decrease with age.

摘要: A rapidly aging global population has motivated the development and use of models for human aging. Studies on have shown parallels between zebrafish humans at internal organization level; however, few been studied whole-organism level. Furthermore, effectiveness exercise as a method to mitigate effects not in zebrafish. We investigated intermittent swimming performance, kinematics behavior. Young, middle-aged old (20-29, 36-48 60-71% average lifespan, respectively) were exercised exhaustion endurance sprint tests once week four weeks. Both performance decreased with increased age. Swimming improved training young zebrafish, but Tail-beat amplitude, which is akin stride length humans, all age groups training. Zebrafish turning frequency, an indicator routine activity, showed no change exercise. In sum, our results show that exhibit decline trainability These findings closely resemble senescence-related declines physical ability experienced by mammalian therefore support model