Pharmacological therapy of spondyloarthritis.
作者： Carlo Palazzi , Salvatore D’Angelo , Michele Gilio , Pietro Leccese , Angela Padula
DOI: 10.1517/14656566.2015.1052744
关键词:
摘要: Introduction: The current pharmacological therapy of spondyloarthritis (SpA) includes several drugs: Non-steroidal anti-inflammatory drugs, corticosteroids, traditional disease-modifying antirheumatic drugs and biologic drugs.Areas covered: A systematic literature search was completed using the largest electronic databases (Medline, Embase Cochrane), starting from 1995, with aim to review data on agents commercialised for SpA treatment. Randomised controlled trials large observational studies were considered. In addition, performed in patients treated other, still unapproved, (rituximab, anti-IL6 agents, apremilast, IL17 inhibitors anakinra) also taken into account.Expert opinion: Biologic especially anti-TNF have resulted significant progress improving clinical symptoms signs, reducing inflammatory features laboratory tests imaging findings, recovering all functional indexes. Anti-TNF radic...
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