Nucleophilic Tetrafluoroethylation Employing in Situ Formed Organomagnesium Reagents
作者： Alena Budinská , Jiří Václavík , Václav Matoušek , Petr Beier
DOI: 10.1021/ACS.ORGLETT.6B02890
关键词:
摘要: Tetrafluoroalkyl bromides are metalated with equimolar iPrMgCl·LiCl (Turbo Grignard) to form organomagnesium compounds which stable at low temperatures and react various electrophiles (aldehydes, ketones, CO2, cyclic sulfate sulfamidate, N-sulfonylimines, nitrone, chlorophosphate, nonaflyl azide) afford novel functionalized tetrafluoroethylene-containing products. Ease of operation, excellent selectivity, high nucleophilicity, enhanced stability the reactive species together a broad substrate scope comprise highly attractive nucleophilic tetrafluoroethylation protocol affording unique synthetic building blocks.
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