Riboflavin attenuates lipopolysaccharide-induced lung injury in rats.
作者： Naif O. Al-Harbi , Faisal Imam , Ahmed Nadeem , Mohammed M. Al-Harbi , Hesham M. Korashy
DOI: 10.3109/15376516.2015.1045662
关键词:
摘要: Riboflavin (vitamin B2) is an easily absorbed micronutrient with a key role in maintaining health humans and animals. It the central component of cofactors flavin adenine dinucleotide (FAD) mononucleotide (FMN) therefore required by all flavoproteins. also works as antioxidant scavenging free radicals. The present study was designed to evaluate effects riboflavin against acute lungs injury induced administration single intranasal dose (20 μg/rat) lipopolysaccharides (LPS) experimental rats. Administration LPS resulted marked increase malondialdehyde (MDA) level (p < 0.01) MPO activity (p < 0.001), whereas decrease glutathione (GSH) content reductase (GR) (p < 0.001) peroxidase activity. These changes were significantly improved treatment dose-dependent manner (30 100 mg/kg, respectively). (100 mg/kg, p.o.) showed similar protective dexamethasone (1 mg/kg, p.o.). cellular including interstitial edema, hemorrhage, infiltration PMNs, etc., which reversed administration. Histopathological examinations normal morphological structures tissue control group. biochemical histopathological examination appended iNOS CAT gene expression. mRNA expression increased levels decreased animals exposed LPS, while both gene. In conclusion, clearly demonstrated that caused effect LPS-induced ALI. results suggest may be used protect toxic lungs.
sci-hub.se 参考文章(49)
C. Little, R. Olinescu, K.G. Reid, P.J. O'Brien, Properties and Regulation of Glutathione Peroxidase Journal of Biological Chemistry. ,vol. 245, pp. 3632- 3636 ,(1970) , 10.1016/S0021-9258(18)62973-4
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Melissa A. Kovach, Theodore J. Standiford, Toll like receptors in diseases of the lung. International Immunopharmacology. ,vol. 11, pp. 1399- 1406 ,(2011) , 10.1016/J.INTIMP.2011.05.013
B. de las Heras, M.J. Abad, A.M. Silván, R. Pascual, P. Bermejo, B. Rodrı́guez, A.M. Villar, Effects of six diterpenes on macrophage eicosanoid biosynthesis. Life Sciences. ,vol. 70, pp. 269- 278 ,(2001) , 10.1016/S0024-3205(01)01402-3
Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Analytical Biochemistry. ,vol. 95, pp. 351- 358 ,(1979) , 10.1016/0003-2697(79)90738-3
Maria Condò, Annio Posar, Annalisa Arbizzani, Antonia Parmeggiani, Riboflavin prophylaxis in pediatric and adolescent migraine. Journal of Headache and Pain. ,vol. 10, pp. 361- 365 ,(2009) , 10.1007/S10194-009-0142-2
Michelle L. Hernandez, Margaret Herbst, John C. Lay, Neil E. Alexis, Willie June Brickey, Jenny P.Y. Ting, Haibo Zhou, David B. Peden, Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers The Journal of Allergy and Clinical Immunology. ,vol. 130, pp. 869- 876 ,(2012) , 10.1016/J.JACI.2012.05.026
Samuel Santos Valenca, Frank Silva Bezerra, Alan Aguiar Lopes, Bruna Romana-Souza, Moisés Clemente Marinho Cavalcante, Aline Brando Lima, Vera Lúcia Gonçalves Koatz, Luís Cristóvão Porto, Oxidative stress in mouse plasma and lungs induced by cigarette smoke and lipopolysaccharide Environmental Research. ,vol. 108, pp. 199- 204 ,(2008) , 10.1016/J.ENVRES.2008.07.001
Michael A. Matthay, Jeanine P. Wiener-Kronish, Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. The American review of respiratory disease. ,vol. 142, pp. 1250- 1257 ,(1990) , 10.1164/AJRCCM/142.6_PT_1.1250
Min-Yung Kuo, Mao-Fang Liao, Fong-Lin Chen, Yi-Ching Li, Ming-Ling Yang, Ruey-Hseng Lin, Yu-Hsiang Kuan, Luteolin attenuates the pulmonary inflammatory response involves abilities of antioxidation and inhibition of MAPK and NFκB pathways in mice with endotoxin-induced acute lung injury Food and Chemical Toxicology. ,vol. 49, pp. 2660- 2666 ,(2011) , 10.1016/J.FCT.2011.07.012