Synthesis of functionalized alkyl substituted benzoquinones by Rh-catalyzed additions of boronic acids
作者： Marcos Veguillas , Jaime Rojas-Martín , María Ribagorda , M. Carmen Carreño
DOI: 10.1039/C7OB00979H
关键词:
摘要: A general synthetic route to γ-oxo alkyl or α-hydroxy benzyl 2-substituted benzoquinones has been developed through a one-pot Rh-catalyzed C–C bond formation/oxidative demethylation sequence from 2,5-dimethoxy aryl boronic acids and several electron deficient alkenes aldehydes. The process allows rapid access functionalized under very mild conditions good yields. We disclose the first example of 1,4-addition reaction benzoquinonyl acid methyl vinyl ketone other conjugate acceptors, which direct synthesis 2-(γ-functionalized alkyl) substituted benzoquinones.
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