Unsteady and Three-Dimensional Simulation of Blood Flow in the Human Aortic Arch

作者: N. Shahcheraghi , H. A. Dwyer , A. Y. Cheer , A. I. Barakat , T. Rutaganira

DOI: 10.1115/1.1487357

关键词:

摘要: A three-dimensional and pulsatile blood flow in a human aortic arch its three major branches has been studied numerically for peak Reynolds number of 2500 frequency (or Womersley) parameter 10. The simulation geometry was derived from the reconstruction series two-dimensional slices obtained vivo using CAT scan imaging on aorta. numerical simulations were projection method, finite-volume formulation Navier-Stokes equations used system overset grids. Our results demonstrate that primary velocity is skewed towards inner wall ascending aorta, but this skewness shifts to outer descending thoracic Within branches, velocities distal walls with reversal along proximal walls. Extensive secondary motion observed structure these flows influenced considerably by presence branches. shear stresses highly dynamic, generally high vicinity low wall, particularly higher than Wall pressure around Comparison our localization early atherosclerotic lesions broadly suggests preferential development regions extrema (either maxima or minima) stress pressure.

参考文章(40)
Frank M. White, Viscous Fluid Flow ,(1974)
H. A. Dwyer, A. Y. Cheer, T. Rutaganira, Highly unsteady flows in curved pipes LNP. ,vol. 515, pp. 153- 158 ,(1998) , 10.1007/BFB0106576
P. F. Davies, Flow-mediated endothelial mechanotransduction Physiological Reviews. ,vol. 75, pp. 519- 560 ,(1995) , 10.1152/PHYSREV.1995.75.3.519
T. Naruse, K. Tanishita, Large curvature effect on pulsatile entrance flow in a curved tube: Model experiment simulating blood flow in an aortic arch Journal of Biomechanical Engineering-transactions of The Asme. ,vol. 118, pp. 180- 186 ,(1996) , 10.1115/1.2795957
David C. Chappell, Signe E. Varner, Robert M. Nerem, Russell M. Medford, R. Wayne Alexander, Oscillatory Shear Stress Stimulates Adhesion Molecule Expression in Cultured Human Endothelium Circulation Research. ,vol. 82, pp. 532- 539 ,(1998) , 10.1161/01.RES.82.5.532
Czeslaw M. Rodkiewicz, Localization of early atherosclerotic lesions in the aortic arch in the light of fluid flow Journal of Biomechanics. ,vol. 8, pp. 149- 156 ,(1975) , 10.1016/0021-9290(75)90096-2
T.L. Yearwood, K.B. Chandran, Physiological pulsatile flow experiments in a model of the human aortic arch. Journal of Biomechanics. ,vol. 15, pp. 683- 704 ,(1982) , 10.1016/0021-9290(82)90023-9