Harnessing Transporters to Clear Uremic Toxins

摘要: The constancy of the milieu interieur described by Claude Bernard is an absolute prerequisite for health organism. primacy kidney in whole organism homeostasis best exemplified disturbance composition and amount body fluid solute when this organ fails to function. In simplistic terms, one can envision renal failure as inability remove what should be excreted add added body. excrete appropriate water various solutes well studied serves a marker clinical practice evaluate degree dysfunction adequacy therapy. There are also many additional substances that not properly failure, accumulation which contributes uremic state, but these less terms their metabolism, mechanism action, or mode excretion. The expanding group proven putative toxins has recently been highlighted European Uremic Toxin Work Group (http://EUTox.info) count reached over 110 moieties.1 This highly diverse ranges from inorganic organic including acids, guanidine, peptides, indoles, nucleotides, others.2 chemical properties moieties expansive identities, with broad range molecular weight (outside …