Family studies of mephenytoin hydroxylation deficiency.
作者： M Jurima , W Kalow , T Inaba
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摘要: A genetic polymorphism characterized by deficient drug oxidation exists for the hydroxylation of mephenytoin. This deficiency was first recognized in a family study that suggested an autosomal recessive pattern inheritance. To confirm observation, we investigated 28 relatives five poor metabolizers. Subjects ingested 50 mg mephenytoin, and 24-hr urine analyzed hydroxymephenytoin. The pedigree data shown here provide strong evidence mephenytoin is trait.
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