Engineered bacteria as therapeutic agents.
作者： Carlos Piñero-Lambea , David Ruano-Gallego , Luis Ángel Fernández
DOI: 10.1016/J.COPBIO.2015.05.004
关键词:
摘要: Although bacteria are generally regarded as the causative agents of infectious diseases, most inhabiting human body non-pathogenic and some them can be turned, after proper engineering, into ‘smart’ living therapeutics defined properties for treatment different illnesses. This review focuses on recent developments to engineer diverse pathologies, including inflammatory bowel autoimmune disorders, cancer, metabolic diseases obesity, well combat bacterial viral infections. We discuss significant advances provided by synthetic biology fully reprogram therapeutics, novel measures strict biocontainment.
sci-hub.se 参考文章(78)
Nilay M. Gandhi, Alvaro Morales, Donald L. Lamm, Bacillus Calmette-Guérin immunotherapy for genitourinary cancer BJU International. ,vol. 112, pp. 288- 297 ,(2013) , 10.1111/J.1464-410X.2012.11754.X
Candace Bichsel, Dennis Neeld, Takashi Hamazaki, Lung-Ji Chang, Li-Jun Yang, Naohiro Terada, Shouguang Jin, Direct reprogramming of fibroblasts to myocytes via bacterial injection of MyoD protein. Cellular Reprogramming. ,vol. 15, pp. 117- 125 ,(2013) , 10.1089/CELL.2012.0058
Candace Bichsel, Dennis K. Neeld, Takashi Hamazaki, Donghai Wu, Lung-Ji Chang, Lijun Yang, Naohiro Terada, Shouguang Jin, Bacterial Delivery of Nuclear Proteins into Pluripotent and Differentiated Cells PLOS ONE. ,vol. 6, ,(2011) , 10.1371/JOURNAL.PONE.0016465
R. E. Ley, F. Backhed, P. Turnbaugh, C. A. Lozupone, R. D. Knight, J. I. Gordon, Obesity Alters Gut Microbial Ecology Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 11070- 11075 ,(2005) , 10.1073/PNAS.0504978102
Miaomin Zhang, Neil S. Forbes, Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating Journal of Controlled Release. ,vol. 199, pp. 180- 189 ,(2015) , 10.1016/J.JCONREL.2014.12.014
Neil S. Forbes, Engineering the perfect (bacterial) cancer therapy Nature Reviews Cancer. ,vol. 10, pp. 785- 794 ,(2010) , 10.1038/NRC2934
Vanessa K. Ridaura, Jeremiah J. Faith, Federico E. Rey, Jiye Cheng, Alexis E. Duncan, Andrew L. Kau, Nicholas W. Griffin, Vincent Lombard, Bernard Henrissat, James R. Bain, Michael J. Muehlbauer, Olga Ilkayeva, Clay F. Semenkovich, Katsuhiko Funai, David K. Hayashi, Barbara J. Lyle, Margaret C. Martini, Luke K. Ursell, Jose C. Clemente, William Van Treuren, William A. Walters, Rob Knight, Christopher B. Newgard, Andrew C. Heath, Jeffrey I. Gordon, Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice Science. ,vol. 341, pp. 1241214- 1241214 ,(2013) , 10.1126/SCIENCE.1241214
D. Ewen Cameron, Caleb J. Bashor, James J. Collins, A brief history of synthetic biology Nature Reviews Microbiology. ,vol. 12, pp. 381- 390 ,(2014) , 10.1038/NRMICRO3239
Ana Blanco-Toribio, Serge Muyldermans, Gad Frankel, Luis Ángel Fernández, Direct Injection of Functional Single-Domain Antibodies from E. coli into Human Cells PLoS ONE. ,vol. 5, pp. e15227- 12 ,(2010) , 10.1371/JOURNAL.PONE.0015227
K. Westphal, S. Leschner, J. Jablonska, H. Loessner, S. Weiss, Containment of Tumor-Colonizing Bacteria by Host Neutrophils Cancer Research. ,vol. 68, pp. 2952- 2960 ,(2008) , 10.1158/0008-5472.CAN-07-2984