Targeted versus Universal Decolonization to Prevent ICU Infection
作者： Susan S. Huang , Edward Septimus , Ken Kleinman , Julia Moody , Jason Hickok
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摘要: A B S T R AC BACKGROUND Both targeted decolonization and universal of patients in intensive care units (ICUs) are candidate strategies to prevent health care–associated infec tions, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). METHODS We conducted a pragmatic, cluster-randomized trial. Hospitals were randomly assigned one three strategies, with all adult ICUs given hospital the same strategy. Group 1 implemented MRSA screening isolation; group 2, (i.e., screening, isolation, carriers); 3, no patients). Proportional-hazards models used assess differences infection reductions across study groups, clustering according hospital. RESULTS
cedars-sinai.edu参考文章(35)
Hastings Center, Ethical Oversight of Learning Health Care Systems ,(2013)
Michael W. Climo, Kent A. Sepkowitz, Gianna Zuccotti, Victoria J. Fraser, David K. Warren, Trish M. Perl, Kathleen Speck, John A. Jernigan, Jaime R. Robles, Edward S. Wong, The effect of daily bathing with chlorhexidine on the acquisition of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and healthcare-associated bloodstream infections: results of a quasi-experimental multicenter trial. Critical Care Medicine. ,vol. 37, pp. 1858- 1865 ,(2009) , 10.1097/CCM.0B013E31819FFE6D
S. Nijssen, M. J. M. Bonten, R. A. Weinstein, Are Active Microbiological Surveillance and Subsequent Isolation Needed to Prevent the Spread of Methicillin-Resistant Staphylococcus aureus? Clinical Infectious Diseases. ,vol. 40, pp. 405- 409 ,(2005) , 10.1086/427281
Ari Robicsek, Jennifer L. Beaumont, Richard B. Thomson, Geetha Govindarajan, Lance R. Peterson, Topical Therapy for Methicillin‐Resistant Staphylococcus aureus Colonization: Impact on Infection Risk Infection Control and Hospital Epidemiology. ,vol. 30, pp. 623- 632 ,(2009) , 10.1086/597550
Jonathan B. Perlin, Jason D. Hickok, Edward J. Septimus, Julia A. Moody, Jane D. Englebright, Richard M. Bracken, A bundled approach to reduce methicillin-resistant Staphylococcus aureus infections in a system of community hospitals. Journal for Healthcare Quality. ,vol. 35, pp. 57- 69 ,(2013) , 10.1111/JHQ.12008
Daniel J. Morgan, Daniel J. Diekema, Kent Sepkowitz, Eli N. Perencevich, Adverse outcomes associated with contact precautions: A review of the literature American Journal of Infection Control. ,vol. 37, pp. 85- 93 ,(2009) , 10.1016/J.AJIC.2008.04.257
J. Chase McNeil, Kristina G. Hulten, Sheldon L. Kaplan, Donald H. Mahoney, Edward O. Mason, Staphylococcus aureus infections in pediatric oncology patients: high rates of antimicrobial resistance, antiseptic tolerance and complications. Pediatric Infectious Disease Journal. ,vol. 32, pp. 124- 128 ,(2013) , 10.1097/INF.0B013E318271C4E0
Susan S. Huang, Virginia L. Hinrichsen, Rupak Datta, Laura Spurchise, Irina Miroshnik, Kimberly Nelson, Richard Platt, Methicillin-Resistant Staphylococcus aureus Infection and Hospitalization in High-Risk Patients in the Year following Detection PLoS ONE. ,vol. 6, pp. e24340- ,(2011) , 10.1371/JOURNAL.PONE.0024340
Rajiv Jain, Stephen M. Kralovic, Martin E. Evans, Meredith Ambrose, Loretta A. Simbartl, D. Scott Obrosky, Marta L. Render, Ron W. Freyberg, John A. Jernigan, Robert R. Muder, LaToya J. Miller, Gary A. Roselle, Veterans Affairs Initiative to Prevent Methicillin-Resistant Staphylococcus aureus Infections The New England Journal of Medicine. ,vol. 364, pp. 1419- 1430 ,(2011) , 10.1056/NEJMOA1007474
William R. Jarvis, JoAnn Schlosser, Raymond Y. Chinn, Samantha Tweeten, Marguerite Jackson, National prevalence of methicillin-resistant Staphylococcus aureus in inpatients at US health care facilities, 2006. American Journal of Infection Control. ,vol. 35, pp. 631- 637 ,(2007) , 10.1016/J.AJIC.2007.10.009