NOVEL SELECTIVE LIGAND FOR DOPAMINE D3 RECEPTOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF
作者： Cao Yongkai , Cheon Seung Hoon , Kim Kyeong Man , Zhang Zili
DOI:
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摘要: The present invention provides a novel ligand for the dopamine D3 receptor and preparation method therefor. compound, pharmaceutically acceptable salt pharmaceutical composition or thereof are used treatment prevention of schizophrenia, neurodegenerative diseases, particularly Parkinson's disease, drug dependence, addiction, anxiety, depression, etc. features high affinity, specificity, functional selectivity. compound can be to study distribution function D2 subtype receptors mechanism diseases associated with dysfunction D2-like receptors, also disease modification hyperprolactinemia, extrapyramidal symptoms, levodopa-associated movement disorder dyskinesia.
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