30-, 31-, and 32-hydroxybullatacinones: bioactive terminally hydroxylated annonaceous acetogenins from Annona bullata.

摘要: From Annona bullata, three more pairs of new ketolactone Annonaceous acetogenins were isolated by bioactivity-directed isolation. They are hydroxylated adjacent bistetrahydrofuran (THF) and named (2,4-cis trans)-32-hydroxybullatacinone (1 2), trans)-31-hydroxybullatacinone (3 4), trans)-30-hydroxybullatacinone (5 6). The structures elucidated analysis the 1H- 13C-nmr spectra 1-6 their acetates ms tri-trimethylsilyl (TMSi) derivatives as compared with bullatacinone [7]. This is first time that OH groups at successive positions near end aliphatic chain have been reported. All compounds showed potent activities in brine shrimp lethality test against human solid tumor cells culture, selectivities exhibited especially toward colon cancer cell line (HT-29).