Gels as vaginal drug delivery systems.
作者： J. das Neves , M.F. Bahia
DOI: 10.1016/J.IJPHARM.2006.03.012
关键词:
摘要: The vagina has been used as a mucosal drug delivery route for long time. Its single characteristics can be either limitative or advantageous when is considered. Gels are semi-solid, three-dimensional, polymeric matrices comprising small amounts of solid, dispersed in relatively large liquid, yet possessing more solid-like character. These systems have and receiving great deal interest vaginal systems. versatile microbicides, contraceptives, labour inducers, other substances. Although somewhat neglected clinical studies, pharmaceutical characterization gels an important step order to optimize safety, efficacy acceptability. Indeed, the simple formulation gel lead different performances containing same amount active Therefore, this paper discusses summarizes current use research based gels.
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