Relation of PAI-1 and TPA genes polymorphisms to acute myocardial infarction and its outcomes in Egyptian patients.
作者： Tarek A. Abd El-Aziz , Noha A. Rezk
DOI: 10.1007/S12013-014-0188-X
关键词:
摘要: Endogenous fibrinolysis is a protective mechanism against arterial thrombotic occlusion, which would otherwise lead to permanent tissue damage as acute myocardial infarction (AMI). We aimed investigate the association of plasminogen activator inhibitor-1 (PAI-1) and (TPA) genes polymorphisms with its outcomes in Egyptian patients. 184 patients AMI controls were included study. PAI-1 TPA analyzed by polymerase chain reaction. All followed for complications during their hospitalization. found significant among ID, II genotypes, I allele increased risk 2.1, 3.2, 1.9 fold, respectively. Also, frequencies 4G/4G genotype 4G significantly compared control group. Furthermore, more likely have morbidity mortality without (P = 0.00 0.048, respectively). concluded that gene are associated morbidity. The AMI. There also an between
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Y van den Eijnden-Schrauwen, N Lakenberg, J J Emeis, P de Knijff, Alu-repeat polymorphism in the tissue-type plasminogen activator (tPA) gene does not affect basal endothelial tPA synthesis. Thrombosis and Haemostasis. ,vol. 74, pp. 1202- 1202 ,(1995) , 10.1055/S-0038-1649907
Paul M Ridker, Michael T Baker, Charles H Hennekens, Meir J Stampfer, Douglas E Vaughan, None, Alu-repeat Polymorphism in the Gene Coding for Tissue-Type Plasminogen Activator (t-PA) and Risks of Myocardial Infarction Among Middle-aged Men Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 17, pp. 1687- 1690 ,(1997) , 10.1161/ATVB.17V09.1687
S.J. Dawson, B. Wiman, A. Hamsten, F. Green, S. Humphries, A.M. Henney, The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells. Journal of Biological Chemistry. ,vol. 268, pp. 10739- 10745 ,(1993) , 10.1016/S0021-9258(18)82047-6
Augusto Di Castelnuovo, Roberto Marchioli, Maria Benedetta Donati, Licia Iacoviello, Francesco Burzotta, Francesco Zito, The 4G/5G Polymorphism of PAI-1 Promoter Gene and the Risk of Myocardial Infarction: A Meta-analysis Thrombosis and Haemostasis. ,vol. 80, pp. 1029- 1030 ,(1998) , 10.1055/S-0037-1615408
P. Crainich, N. S. Jenny, Z. Tang, A. M. Arnold, L. H. Kuller, T. Manolio, A. R. Sharrett, R. P. Tracy, Lack of association of the plasminogen activator inhibitor-1 4G/5G promoter polymorphism with cardiovascular disease in the elderly Journal of Thrombosis and Haemostasis. ,vol. 1, pp. 1799- 1804 ,(2003) , 10.1046/J.1538-7836.2003.00255.X
A. Hamsten, P. Eriksson, B. Kallin, F. M. van 't Hooft, P. Bavenholm, Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 1851- 1855 ,(1995) , 10.1073/PNAS.92.6.1851
R G McKay, M A Pfeffer, R C Pasternak, J E Markis, P C Come, S Nakao, J D Alderman, J J Ferguson, R D Safian, W Grossman, Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion. Circulation. ,vol. 74, pp. 693- 702 ,(1986) , 10.1161/01.CIR.74.4.693
Jingzhong Ding, Barbara J Nicklas, Margaret D Fallin, Nathalie de Rekeneire, Stephen B Kritchevsky, Marco Pahor, Nicolas Rodondi, Rongling Li, Joseph M Zmuda, Tamara B Harris, None, Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke. American Heart Journal. ,vol. 152, pp. 1109- 1115 ,(2006) , 10.1016/J.AHJ.2006.06.021
S. D. ROBINSON, C. A. LUDLAM, N. A. BOON, D. E. NEWBY, Tissue plasminogen activator genetic polymorphisms do not influence tissue plasminogen activator release in patients with coronary heart disease Journal of Thrombosis and Haemostasis. ,vol. 4, pp. 2262- 2269 ,(2006) , 10.1111/J.1538-7836.2006.02124.X
Waqas Ahmed, Meera Malik, Imran Saeed, Amina Ali Khan, Ahmed Sadeque, Umar Kaleem, Nuzhat Ahmed, Muhammad Ajmal, Maleeha Azam, Raheel Qamar, Role of tissue plasminogen activator and plasminogen activator inhibitor polymorphism in myocardial infarction Molecular Biology Reports. ,vol. 38, pp. 2541- 2548 ,(2011) , 10.1007/S11033-010-0392-8