Distribution of Vitamin A, Retinol-Binding Protein, Cellular Retinoic Acid-Binding Protein I, and Retinoid X Receptor β in the Porcine Uterus During Early Gestation

摘要: Retinol and retinol-binding protein (RBP), among the major secretory products of uterine endometrium in fluid pigs, are assumed to be importance for early embryonic development. While RBP has been widely characterized, little information is available on metabolism vitamin A itself or other specific binding proteins nuclear receptors uterus pigs. In present study, content distribution tissue pigs during gestation (Days 14-30) were examined macroscopically microscopically via autofluorescence HPLC. addition, involved at cellular level was investigated. Macroscopically, yellowish-greenish characteristic observed endometrium. Microscopy showed that associated with glandular surface epithelium these structures, immunoreactive localized, as retinoic acid-binding I. Retinoid X receptor beta nucleus myometrium The intensity fluorescence decreased progress gestation. This decrease paralleled by a myometrium. general, concentration higher than (P < 0.01). myometrium, if all, found almost exclusively retinyl esters. endometrium, dominant fraction retinol, representing more 90% total A. These results show first time pig can attributed Differences form might point differences metabolism. stored, primarily retinol-the which it secreted into fluid.