Techniques to Determine Clonality in Hematolymphoid Malignancies
作者： Daniel E. Sabath
DOI: 10.1007/978-1-4419-5698-9_8
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摘要: Clonality testing is a well-established molecular diagnostic technique in the realm of hematopathology. Molecular techniques to diagnose hematological malignancies based on detection clonality have been with us since mid-1980s, seminal observation that lymphoid cells rearrange their antigen receptor genes and recurrent genetic rearrangements are present myeloid neoplasms. In this chapter, I review history cancer, describe scientific principles which clonality-based rest, then numerous now available for diagnosing hematolymphoid by demonstrating clonal nature.
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