Tumor cell phenotype and heterogeneity differences in IDH1 mutant vs wild-type gliomas
作者： Michael E. Berens , Anup Sood , Jill S. Barnholtz-Sloan , John F. Graf , Sanghee Cho
DOI: 10.1101/690297
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摘要: Abstract Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and interactions have not been well characterized. To gain new clinical- biological-insights into the genetically-bifurcated IDH1 mutant (mt) vs wildtype (wt) forms of glioma, we integrated multiplexed immunofluorescence single cell data for 43 protein markers across cancer hallmarks, in addition spatial metrics, genomic sequencing magnetic resonance imaging (MRI) quantitative features. Molecular heterogeneity scores angiogenesis invasion differ between IDHmt wt gliomas irrespective prior treatment tumor grade; these differences also persisted MR features peritumoral edema contrast enhancement volumes. Longer overall survival IDH1mt glioma patients may reflect generalized altered cellular, molecular, which manifest discernable radiological manifestations.
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