Canine parvovirus infection potentiates canine distemper encephalitis attributable to modified live-virus vaccine.

摘要: Twelve gnotobiotic dogs from 2 litters were allotted to 3 groups. Group A received a modified-live polyvalent (canine distemper, adenovirus type 2, and parainfluenza virus Leptospira -canicola-icterohemorrhagiae bacterin) vaccine days prior oral inoculation with canine parvovirus (CPV). B CPV alone. C 1 dose of only. In none the 9 CPV-inoculated did clinical signs infection develop, although high serum antibody titers for developed in all them. However, 5 vaccinates, distemper encephalomyelitis subsequently developed. The results suggested that exerts an immunomodulating effect on immune responses may be responsible vaccination failures dogs.