Genistein alleviates β-amyloid-induced inflammatory damage through regulating Toll-like receptor 4/nuclear factor κB.
作者： Rong Xiao , Weiwei Ma , Bingjie Ding , Huanling Yu , Linhong Yuan
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摘要: Abstract Genistein (GEN), a major soybean isoflavone (SIF), might possess neuroprotective properties through its anti-inflammatory activity. We hypothesized that GEN could prevent the inflammatory damage detected in C6 cells induced by β-amyloid peptides 25-35 (Aβ25-35). Accordingly, we evaluated Aβ25-35 and protective effect of against cells. In our study, glial (rats glioma cell lines) were preincubated with or without for 2 h following incubation another 24 h. Then, methylthiazolyl tetrazolium (MTT) assay was used to assess viability. Immunofluorescence staining identify Inflammatory factors tumor necrosis factor (TNF)-α interleukin (IL)-1β analyzed using enzyme-linked immunosorbent (ELISA). Western blot analysis reverse transcription-polymerase chain reaction performed expression Toll-like receptors 4 (TLR4), inhibitor kap...
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