Plasma Membrane ATPase: Potential Target for Antifungal Drug Therapy

摘要: Fungal plasma membrane H+-ATPase (PM-ATPase) is crucial to cell physiology as it maintains an electrochemical proton gradient across membranes required for the uptake of nutrients. It regulates intracellular pH and dimorphic transition that directly linked with growth pathogenicity fungus. Opportunistic fungal pathogens, mainly Candida spp., lead complications in HIV-infected other immunocompromised patients. Due eukaryotic nature cells, difficult identify unique antifungal targets not shared human hosts. Also currently available drugs have low efficacy high toxicity frequently drug resistance. They undesirable side effects are ineffective against reemerging fungi. Treatment options invasive infections limited almost always involve use nephrotoxic amphotericin B azoles, which resistance on prolonged probably due their fungistatic nature. There thus a critical need develop more effective therapies deal such infections, natural products offer safer alternative. PM-ATPase cells hence promising target. will help development new mechanism-based drugs. Intracellular glucose-induced H+ efflux, consequences activity, inhibited by compounds same extent both susceptible resistant strains. Several plant essential oil constituents inhibit activity significantly may be considered good candidates designing specific surface active target ultimately curbing pathogenic