Diabetes-associated depression: The serotonergic system as a novel multifunctional target

摘要: Diabetes associated depression is a largely understudied field which nonetheless carries significant disease burden. The very low therapeutic efficacy of the existing conventional drugs with poor outcome may be, in part, due to uncertainty mechanism involved that clearly explains comorbidity. main purpose this review was address sophisticated mechanisms comorbidity view developing potential novel targets higher and specificity. Data were collected from database searches including PubMed, references relevant English language research/review articles other official publications. Articles 1990 2013 included, broad search term criteria followed for data mining so information not missed out. Some terms used included; diabetes-induced depression, diabetes serotonin, hypothalamic-pituitary-adrenal (HPA) axis glucocorticoids diabetes. Neuropathologically, depletion brain monoaminergic activity specifically serotonin (5-hydroxytryptamine [5-HT]) system, chronically persisting diabetic state lead mood behavioral complications further add on worsening quality life years. 5-HT system through multifunctional tasks regulates neurogenesis plasticity by complex receptor controls emotional activity. Persisting hyperglycemia leads impaired neurogenesis, decreased synaptic plasticity, undesired neuro-anatomical alterations, neurochemical deficits, reduced neurotransmitter neurotrophic factors secondary messenger functions affected at molecular genetic levels indicate impact diabetes-mediated dysregulation neuronal circuits. HPA activity, glycogen synthase kinase 3, insulin signaling also found be hampered, interlinked following progression.