Human melanoma antigens recognized by T lymphocytes.

摘要: Human melanoma antigens and their epitopes recognized by T cells have been identified using a variety of methods. These are classified as 1) melanocyte specific melanosomal proteins (MART-1, gp100, tyrosinase TRP-1), 2) expressed in testis cancers (MAGE-1, MAGE-3, BAGE GAGE), 3) tumor mutated (beta-catenin, MUM-1 CDK4), 4) others (p15). Some the HLA-A2 binding non-mutated contained non-dominant anchor amino acids relatively low affinity, suggesting that these were likely to be subdominant or cryptic self determinants. The significant correlation observed between vitiligo development IL2 based immunotherapy suggested autoreactive for peptides involved regression vivo. In addition, since adoptive transfer into patients CTL recognizing resulted regression, may rejection antigens. Melanoma reactive efficiently induced from PBL vitro stimulation with PBMC pulsed useful protocols treatment metastatic melanoma. An immunization trial MART-1 gp100 conjunction incomplete Freund's adjuvant is progress. new immunotherapies well understanding mechanisms anti-tumor immune responses autoimmune disorders against melanocytes.