作者: Glen D. Leesman , Gordon L. Amidon , Lizbeth B. Sherman
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摘要: A drug delivery system includes a first capsule half having an inner chamber for containing therein. plug is disposed in passageway of the plugging opening thereof. The releasable from upon application pressure within chamber. pump mechanism causes increase and forces out to release thereby providing second pulse at predetermined time after initial ingestion capsule. invention further provides method manufacturing by which body.