Tryptophan degradation in patients infected by human immunodeficiency virus.

摘要: Tryptophan and kynurenine were measured retrospectively in sera of 11 male patients with advanced human immunodeficiency virus (HIV) infection (Walter Reed stages 4 6). levels are significantly reduced to less than 50% HIV elevated when compared sex age matched controls. The decrease tryptophan might contribute neurologic symptoms often associated infection. Since interferon-gamma induces degradation via the pathway, present results may be consistent enhanced endogenous production