Androgen-mediated Control of the Cyclin D1-RB Axis: Implications for Prostate Cancer
作者： Karen E. Knudsen , Clay E.S. Comstock , NicholasA. Olshavsky , Ankur Sharma
DOI: 10.1007/978-3-540-73855-8_7
关键词:
摘要: Prostatic adenocarcinomas are exquisitely dependent on androgen via its cognate receptor (the receptor, AR) for proliferation and survival. This dependence is exploited in the treatment of disseminated disease, wherein ablation AR activity constitutes first line therapeutic intervention.While initially effective, these strategies ultimately fail, due to inappropriate restoration AR-mediated cellular proliferation. Resultant studies revealed that governs cyclin D1-RB axis, addition other phases cell cycle. Strikingly, have unexpected cross talk between several elements cyclemachinery, aberrations pathways been associated with disease progression. In this review, molecular communication axis will be discussed, an emphasis implications prostate cancer progression management.
springer.com
sci-hub.st 参考文章(108)
Charles Huggins, Clarence V. Hodges, Studies on prostatic cancer The Journal of Urology. ,vol. 167, pp. 948- 951 ,(2002) , 10.1016/S0022-5347(02)80307-X
Myles C. Hodgson, Inna Astapova, Shinta Cheng, Larissa J. Lee, Manon C. Verhoeven, Eunis Choi, Steven P. Balk, Anthony N. Hollenberg, The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists. Journal of Biological Chemistry. ,vol. 280, pp. 6511- 6519 ,(2005) , 10.1074/JBC.M408972200
Charles J. Ryan, Alex Smith, Priti Lal, Jaya Satagopan, Victor Reuter, Peter Scardino, William Gerald, Howard I. Scher, Persistent prostate-specific antigen expression after neoadjuvant androgen depletion: An early predictor of relapse or incomplete androgen suppression Urology. ,vol. 68, pp. 834- 839 ,(2006) , 10.1016/J.UROLOGY.2006.04.016
Ping Zhu, Sung Hee Baek, Eliot M. Bourk, Kenneth A. Ohgi, Ivan Garcia-Bassets, Hideki Sanjo, Shizuo Akira, Paul F. Kotol, Christopher K. Glass, Michael G. Rosenfeld, David W. Rose, Macrophage/Cancer Cell Interactions Mediate Hormone Resistance by a Nuclear Receptor Derepression Pathway Cell. ,vol. 124, pp. 615- 629 ,(2006) , 10.1016/J.CELL.2005.12.032
S. Chen, Y. Xu, X. Yuan, G. J. Bubley, S. P. Balk, Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 15969- 15974 ,(2006) , 10.1073/PNAS.0604193103
David A. Solomon, Ying Wang, Sejal R. Fox, Tah C. Lambeck, Sarah Giesting, Zhengdao Lan, Adrian M. Senderowicz, Erik S. Knudsen, Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. Journal of Biological Chemistry. ,vol. 278, pp. 30339- 30347 ,(2003) , 10.1074/JBC.M303969200
Elisabeth D. Martinez, Mark Danielsen, Loss of Androgen Receptor Transcriptional Activity at the G1/S Transition Journal of Biological Chemistry. ,vol. 277, pp. 29719- 29729 ,(2002) , 10.1074/JBC.M112134200
J. Trapman, A.O. Brinkmann, The androgen receptor in prostate cancer. Pathology Research and Practice. ,vol. 192, pp. 752- 760 ,(1996) , 10.1016/S0344-0338(96)80097-5
Christine Kaltz-Wittmer, Ulrich Klenk, Axel Glaessgen, Daniela E Aust, Joachim Diebold, Udo Löhrs, Gustavo B Baretton, FISH analysis of gene aberrations (MYC, CCND1, ERBB2, RB, and AR) in advanced prostatic carcinomas before and after androgen deprivation therapy Laboratory Investigation. ,vol. 80, pp. 1455- 1464 ,(2000) , 10.1038/LABINVEST.3780152
Ahmed El Gedaily, Lukas Bubendorf, Niels Willi, Wenting Fu, Jan Richter, Holger Moch, Michael J. Mihatsch, Guido Sauter, Thomas C. Gasser, Discovery of new DNA amplification loci in prostate cancer by comparative genomic hybridization. The Prostate. ,vol. 46, pp. 184- 190 ,(2001) , 10.1002/1097-0045(20010215)46:3<184::AID-PROS1022>3.0.CO;2-8