A potential clinical significance of DAB2IP and SPRY2 transcript variants in prostate cancer

摘要: Abstract Deregulation of key signaling pathways is one the primary phenomena in carcinogenesis. DAB2IP and SPRY2 are regulatory elements, which act as feedback inhibitors receptor tyrosine kinases mitogen-activated protein kinase pathway. These elements have also been implicated pathophysiology cancer. Therefore, this study aimed to investigate expression all known splice variants prostate tissue. Fresh Prostate tissue samples (50 cancer/ matched normal 30 BPH) were collected total RNA was extracted followed by cDNA synthesis. The transcript evaluated using RT-PCR quantitative Real-time PCR. results indicated significant down-regulation variant 1 cancerous tissues compared paired (P = 0.001) well 2 comparison with counterparts BPH (P = 0.008 P = 0.025, respectively). In addition, there a negative correlation between DAB2IP.1 SPRY2.2 PSA levels cancer (P = 0.039 ρ =−0.24 P = 0.045 =−0.3, Interestingly, mRNA positively correlated tumor (P = 0.002 ρ = 0.434). For first time, experiment highlights deregulation human present confirms extends previous reports through indicating transcript-specific association tumorigenesis.