New design for clinical trial of antihypertensive drugs applied to pindolol, clopamide, and combinations thereof.

摘要: Abstract A β-blocker (pindolol) and a diuretic (clopamide) were given in different dosages, singly two combinations, to 71 patients with mild moderate essential hypertension. The trial design was such that took both drugs combination, doses, according set plan. best regimen for each patient determined by taking into account not only blood pressure but also resting heartrate, body-weight, serum potassium, urate. For 19 (27%) monotherapy best—pindolol 16 clopamide 3. the remaining patients, combination of pindolol 10 mg 5 39, 35 these one tablet daily sufficient. All reached preset target blood-pressure. differences proportions responding following pairs regimens compared—monotherapy vs mg-were significant (2p